Advantages and disadvantages of a six volt format vs a 12 volt format.
Here are some disadvantages:
Higher resistance due to the external series connection VS internal in a 12 volt.
The external connection is mission critical and is exposed to the possibilities of corrosion far more than the internal connection in a 12 volt format.
Lower ability to produce high amp hour draws for long periods of time (100 amps of load for example)
If the six volt batteries are not totally matched as far as amp-hours then the total output is limited by the "weaker" of the two batteries. I.E. one six volt battery at 90 amp-hours and one at 100 amp-hours will result in a 12 volt battery with a capacity of only 90 amp-hours. If they were twelve volt in parallel and the batteries were 45 amp-hours and 50 amp-hours the total would be 95 amp-hours of capacity. Amps in series don't "add" and amps in parallel *do* add.
For the same size "box" 12 volt format seems to have more total number of amp-hours, which is the most important number for us.
If there is room for three batteries the 12 volt format has the possibility of a 50% advantage on the number of amp-hours of storage.
If one six volt fails then you have no 12 volt power at all. (this would be rare, but possible)
There are also some myths:
Six volt batteries do not have a longer life span, nor do they have greater capacity. They do have thicker plates but the rate of chemical reaction has to run twice as fast–so there no advantage over a 12 volt format as far as life span or capacity.
Advantages of six volt format:
Six volt batteries may possibly better at withstanding mechanical vibrations.
It is harder to wire a six volt based system safely but incorrectly. Many, if not most 12 volt systems may be safely wired–but not correctly balanced. When that imbalance happens it is disastrous as far as both capacity and life span. Hence the myth that six volt is better and lasts longer.
All that said, if you treat your six volt batteries well, or your twelve volt batteries, or your 2 volt batteries and charge them up to 100% state of charge as often as is possible, they will serve you well.